A new laboratory study shows that the A.30 coronavirus variant, which was detected in Angola as well as Sweden, is extremely resistant to the antibodies produced by AstraZeneca and Pfizer vaccines.
A german team looked into the A.30 rare variant, which was initially discovered in Tanzania but later found in many patients in Angola as well as in Sweden. The mutation was compared to Eta and Beta variants. The Beta variant was chosen for its ability to reproduce the Eta mutation. “the highest level”Researchers said that the resistance was due to antibody.
According to the study published in the peer-reviewed journal Cellular & Molecular Immunology this week, the A.30 variant showed improved ability to enter most host cells, including kidney, liver, and lung cells.
The mutation “enters certain cell lines with increased efficiency and evades antibody-mediated neutralization,”This was the conclusion of the study.
“In summary, A.30 exhibits a cell line preference not observed for other viral variants and efficiently evades neutralization by antibodies elicited by ChAdOx1 nCoV-19 [AstraZeneca](or BNT162b2) [Pfizer] vaccination.”
It was resistant to Bamlanivimab monoclonal drug, used in Covid-19 treatment. However, it was sensitive to Etesevimab and Bamlanivimab.
A.30 is not yet listed as an interest/concern variant by the World Health Organization, (WHO), due to its low prevalence.
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