About 100 people demonstrated in Worcester last month against the cloning of human beings by Advanced Cell Technology. The protest was sponsored by the Life Action League of Massachusetts, the Massachusetts Family Institute and other groups.
Cloning at Worcester’s ACT Supported by Mass. Congressional Delegation

Cells from Adult Skin May Be Just As Useful as Cloned Cells

By Amy Contradaa
January 2002

Even though stem cells from adult human skin may be just as effective for medical research as those taken from clones according to new research, the pressure to allow cloning continues. 

Despite the new studies, both Sen. Kennedy and Kerry are expected to be prominently in favor of cloning in the battle that is ensuing since the Worcester company, Advanced Cell Technology, announced on November 24 its preliminary successes in the cloning of human embryos. 

Kennedy is obviously eager to support the cloning. “I strongly oppose the use of cloning technology to reproduce a human being,” Kennedy said. “But we must also protect essential areas of medical research involving cloning technology, including stem-cell research.” Senator Kerry, who has consistently voted pro-abortion, can be expected to follow suit. The Senate debate on the cloning ban will likely not begin before February or March.

On one side are those who argue that such a ban should only forbid the cloning of human beings who are allowed to live (called “reproductive” cloning) while still permitting cloning for medical research and therapies where the cloned embryo is allowed to live for only a few days (known as “therapeutic” cloning).

Included in those who favor cloning for research are those who fear the enactment of any law which would identify the earliest moment of conception as the beginning of human life. These include the powerful biotech lobby and many scientific organizations.

On the other side are those who believe that all human embryos are just that – human – and that once on the slippery slope, reproductive cloning will inevitably follow. As the President’s new bioethics advisor, Leon Kass, has said, “Once the embryonic clones are produced in laboratories, the eugenic revolution will have begun, and we will have lost our chance to do anything about it.”

Will U.S. Ban All Cloning?

Last July, the U.S. House of Representatives passed a ban on both types of cloning by a 265-162 vote. No one from the Massachusetts delegation voted for the ban. (Such a ban would affect all U.S. scientists, not only those receiving federal money.) President Bush has urged the Senate to act swiftly to do the same. But quite a few Senators are balking, including Ted Kennedy.

Laurie Letourneau, President of the Life Action League of Massachusetts, told MassNews that it is “obscene” that the entire Massachusetts Congressional delegation supports experimentation on cloned human embryos.

The state of Massachusetts could also forbid human cloning. Three bills to do that were given a hearing on December 12 at the State House (S. 1794, S. 1808, S. 1809). They seek to ban only reproductive human cloning, but would allow cloning of human cells, human tissue, or human organs that would not result in the replication of a full-grown  human being. (Massachusetts Citizens for Life originally filed one of these bills in 1999-2000.)

Letourneau said of the state legislators, “I don’t think they have the moral guts to ban cloning.” Dan Avila of the Massachusetts Catholic Conference told MassNews, “It’s too early to tell what will happen in Massachusetts.” He is “banking that the ball game will be played mostly in Congress.”

Bishop Reilly, Jews for Life, Condemn ACT

Reacting to ACT’s announcement, Bishop Daniel P. Reilly of Worcester has stated: “[N]oble ends cannot justify morally repugnant means. … Cloning human beings even at the embryonic stage is rife with other moral dilemmas from many philosophical viewpoints. It robs people of their gift of individuality; it reduces reproduction to a manufacturing process devoid of love or even human interaction; worse still, it treats human life as a commodity to be owned and traded, bought or sold. It is the manufacture of a separate class of life for enslavement.”

The Bishop continued: “Since adult, stem-cell research has shown equal if not greater promise utilizing morally acceptable means, the need for therapeutic cloning is still not clear. I ask that our legislators move swiftly to ban human cloning for the protection of our Commonwealth and humanity as a whole and, in so doing, publicly acknowledge this scientific breakthrough for what it is, an ethical breakdown.”

A powerful voice against human engineering comes from a group especially sensitive to the dangers of medical experimentation on humans, Jews for Life. Their founder, Bonnie Chernin Rogoff, commented to MassNews:

“No matter what reassurances we hear from Dr. Michael D. West of Advanced Cell Technologies, cloning human babies will inevitably happen, because scientific discovery is rarely a means to an end, but rather leads to more experimentation to satisfy a demand.  I see cloning as a horrific unnatural means to satisfy the human demand for perfection, and immortality. Cloning embryos to cure diseases is only the start.

“Cloning will ultimately be used for elective reasons; for example, to assist infertile couples achieve immortality through replication, by duplicating the husband’s genetic code in order to provide a replacement model.  A moral line has been crossed.

“Secular humanists have a dual goal: to rid the world of people deemed inconvenient or unfit, via abortion and assisted suicide, and then to improve on God’s creation and replace God’s will with the people’s will.  But not all people are good.  What happens if some evil scientists with bad ideas decide to use cloning techniques to create a master race?  What happens once a way is found to replace our own bodies with new models via cloning?  What happens when some experiments go awry?  The implications and risks involved in such experiments are too horrible to contemplate.

“If the demand for perfection rises in proportion to the ability for science to provide the ideal, and a strong foundation in God is absent, the appalling result will be cloning clinics that will attempt to breed ‘supreme’ beings for profit.”

What ACT Has Done

Dr. Michael West, CEO of Advanced Cell, has said, “The most fundamental problem of humanity remains aging.” He claims his company is just looking for ways to help those suffering from disease and he has no intention of cloning a complete human being.

The company is trying to use cloned human embryos to produce stem cells. Theoretically, the advantage of this over using stem cells from other sources is that therapeutic tissues can be grown from a patient’s own cells, thereby avoiding rejection of the cells by the patient’s immune system. West predicts it will be at least 10 years before any applications may be available to the public.

However, this goal may likely be reached, say other researchers, without recourse to cloning. Adult stem cells are already showing possibly even greater promise for therapeutic applications than embryonic stem cells. Robert Bazell, NBC medical reporter, has said that “until now, researchers thought that stem cells offer the best hope for rebuilding damaged organs, but [the] latest research shows that the embryos, which are politically controversial, may not be necessary.”

Leon Kass labels the whole excursion into “therapeutic” cloning “science fiction.”

ACT has charted its course, however. There seems to be a breathlessness to the stories of ACT’s production of several embryos, which grew only to the four-cell size and in one case six cells, before they stopped growing. (The embryo needs to grow to about a hundred cells before stem cells can be harvested.) It appears the company is trying to get as much out into the public eye as possible before legislative bodies have time to absorb it all, and possibly halt their work.

The latest research is detailed in a US News & World Report cover story (December 3, 2001), which makes heroes of ACT scientists in a fawning account of their all-nighters at the lab. West, Cibelli, and Lanza have summarized their embryonic cloning work in a Scientific American story (11/24/01), and have published their results in a scientific journal as well.

Will ACT Leave USA?

On November 25, West appeared on NBC’s Meet the Press, with Tim Russert and NBC’s Bazell. It is not clear whether ACT would leave the country if a total ban on cloning is passed by the Congress and signed by the President. West seems to waffle in his answer:

“Russert: If this bill is … passed by the Senate, signed into law by President Bush, you’d be fined $1 million and up to 10 years in prison.

West: That’s right.

Russert: Are you prepared for that?

West: Well, we wouldn’t do it in that case.

Russert: You would stop your research?

West: Well, we wouldn’t break the law, of course. It’d be a tragic day in the history of medicine. ...

Russert: Would you take your research overseas if it was banned in the United States?

West: I don’t know the answer to that. I’m optimistic that we’re the leading technological country in the world, and I think in some respects, the moral leader in the world. ...  I believe the technique has a great deal of merit and will be allowed to move forward.”

Does ACT Plan to Clone a Human Baby?

ACT may indeed be thinking of cloning a human baby, implanting a cloned embryo in a woman, in the near future. Bazell asked West why ACT released its report on the 80% healthy rate of their cloned cows, just one week before their human embryo cloning announcement.

(The reliability of the cow report has been contested by Professor Rudolf Jaenisch of MIT’s Whitehead Institute. Jaenisch also worried that people interested in cloning humans would use the study to defend their work as “safe,” according to a Reuters story.)

The interview on Meet the Press continued:

Bazell: So if you’re not going down the track toward cloning human beings, how come you’re making such a big deal about the cows being healthy?

West: Well, we’re trying to be accurate….

Russert: [In Scientific American], in an article written by you and your colleagues, you say this. “We believe that reproductive cloning has potential risk to both mother and fetus that make it unwarranted at this time and we support a restriction on cloning for reproductive purposes until the safety and ethical issues surrounding it are resolved.”

West: Right.

Russert: [You say], “At this time, until safety and ethical issues are resolved.” You do not have any moral reservations to cloning. You just want to delay it until you’re more comfortable with it?

West: Well, this article is us speaking as individuals and scientists. I’m not an expert in ethics.

Follow the Money

ACT is a privately owned company. But in October its website announced that the company had received a grant from the federal government’s National Institute of Standards and Technology for $1,890,000. The funds are to support research into “transdifferentiation,” which “focuses on developing specialized adult cell types of the central nervous system,” without using “animal or human oocytes, embryos or embryonic stem cells.”

The Los Angeles Times reported. “[A government official] said the terms of the grant specifically forbid the company from using the federal money to conduct research on human cloning. ‘We have audit procedures in place to make sure that doesn’t happen.’”

The article also mentions the media blitz accompanying the recent cloning announcement, and states that some in the scientific community are speculating “as to whether the company hopes to use the publicity to attract investors.”

The Boston Globe reported that the University of Massachusetts stands to gain from future ACT profits. Specifically, UMass. will receive 4.5% of the company’s net sales according to a 1998 licensing deal. President Bulger’s spokesman told the Globe, “It’s an area fraught with legal, ethical, and moral considerations. ... I haven’t heard anyone suggest the University will somehow be held culpable for this.”

Duncan Holly Biomedical of Somerville helped collect human eggs for ACT’s experiments. Seven Boston-area women were donors, earning about $4,000 apiece (or about $40/hour).

For a little black humor, Forbes magazine (6/29/01) ran a story entitled, “We cloned you, now, here’s the bill.” According to their fictional tally, a cloned human baby will run around $1.7 million. “We assumed that this cloning effort would be clandestine, because it appears cloning will be illegal in many countries.”

Atty. Susan Gay, director of the Pro-Life Legal Defense Fund of Massachusetts, and executive vice-president of Massachusetts Citizens for Life, sees the almighty dollar as prime motivator at ACT. She told MassNews:

“The ends touted by biotech firms are grossly speculative in the first instance, and, if attainable at all, will be achieved by a means which is indefensible. ... Our nation has historically sought to protect the weak and the defenseless from exploitation whether by unbridled capitalists or by the intelligentsia. Our biotech industries represent both, and are seeking carte blanche for their boundless venture into the uncharted realm of asexual human generation. ... It will fall to our legislature in this next year to muster the courage to ‘just say no’ to those who would stop at nothing unless a serious governmental sanction looms larger than the dollar signs on the horizon.”

ACT’s Board of Ethical Advisors

Three Massachusetts women were named in the Scientific American article as members of ACT’s ethical advisory board: Judith Bernstein of Boston University; Susan Crockin, a health care lawyer in private practice in Newton; and Susan R. Levin, a counselor in private practice in West Roxbury. Professor Ronald M. Green, director of the Ethics Institute at Dartmouth College, is chairman.

The Slippery Slope

The birth control pill was developed in Worcester. Now, the first known cloning of human embryos has happened there. Letourneau said she feels like she’s living at the “ground zero” source of some of the most damaging scientific work ever done. While West may ridicule the slippery slope theory, many residents of that city are wondering just what’s been oiling their hills.

Not only Catholics, but many people concerned with the protection of human dignity, are seeing the wisdom in the warning about where such medical “advances” would eventually lead us.

West has tried to demean the opponents of embryonic cloning research as hopelessly old-fashioned. He told Meet the Press, “You know, when IVF [in-vitro fertilization] was first being discussed, the same opponents, by the way, of this application of cloning and medicine, were against IVF. And they said, ‘Test tube babies, brave new world,’ and we’re hearing the same individuals and the same words against the medical uses of cloning technology.”

The Catholic Church still opposes IVF, though perhaps more quietly now (out of consideration for the many IVF children and families?). The Church’s belief that the birth control pill and IVF were at the top of a slippery slope they believe was prescient. Scientists are now indeed engineering babies, “creating” life, performing “near miraculous” feats, to use West’s words.

Once cloned children are among us, will opposition to the procedure become more muted – out of consideration for the cloned and their families?

Pope John Paul II urged President Bush last July to bar medical experimentation using human embryos. The Pope said: “Experience is already showing how a tragic coarsening of consciences accompanies the assault on innocent human life in the womb, leading to accommodation and acquiescence in the face of other related evils, such as euthanasia, infanticide, and most recently, proposals for the creation for research purposes of human embryos, destined to destruction in the process.”

Polls show a large majority of Americans oppose reproductive cloning. But they apparently have also accepted West’s distinction that there are two kinds of cloning, and they favor “therapeutic” cloning by a slight majority.

Scientists hold great public trust in our secular age. But many Americans would still agree with Rep. Chris Smith of New Jersey: “Mad scientists are still mad scientists no matter how white their lab coats are and how many bioethicists they hire to justify their actions.”

An extensive story on cloning by Amy Contrada can be found in the September 2001 issue in the MassNews archives.

 

 

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